Tag: radiology

AI Boosts DBT in Detecting More Breast Cancer

Posted on by Brian Casey

A real-world study of AI for DBT screening found that AI-assisted mammogram interpretation nearly doubled the breast cancer detection rate. Radiologists using iCAD’s ProFound AI software saw sharp improvements across multiple metrics. 

Mammography screening has quickly become one of the most promising use cases for AI. 

  • Multiple large-scale studies published in 2024 and 2025 have documented improved radiologist performance when using AI for mammogram interpretation, with the largest studies performed in Europe.

Another new technology changing mammography screening is digital breast tomosynthesis, which is being rapidly adopted in the U.S. 

  • DBT use in Europe is occurring more slowly, so questions have arisen about whether AI’s benefits for 2D mammography would also be found with 3D systems.

To investigate this question, researchers writing in Clinical Breast Cancer tested radiologist performance for DBT screening before and after implementation of iCAD’s ProFound V2.1 AI algorithm in 2020 at Indiana University. 

  • Interestingly, the pre-AI period included use of iCAD’s older PowerLook CAD software. 

Across the 16.7k DBT cases studied, those with AI saw …

  • A sharp improvement in cancer detection rate per 1k exams (6.1 vs. 3.7).
  • A decline in the abnormal interpretation rate (6.5% vs. 8.2%).
  • Higher PPV1 (rate that abnormal mammograms would be positive) (8.8% vs. 4.2%).
  • Higher PPV3 (rate that biopsies would be positive) (57% vs. 32%). 
  • Higher specificity (94% vs. 92%).
  • No statistically significant change in sensitivity.

The findings on sensitivity are curious given AI’s positive impact on other interpretation metrics.

  • Researchers postulated that there was higher breast cancer incidence in the post-AI implementation period, which could have been caused by AI finding cancers that were missed in the period without AI.

The Takeaway

The radiology world has seen multiple positive studies on AI for mammography, but most of these have come from Europe and involved 2D mammography not DBT. The new results suggest that AI’s benefits will also transfer to DBT, the technology that’s becoming the standard of care for breast screening in the U.S.

How Do Patients Feel about Mammo AI?

Posted on by Brian Casey

As radiology moves (albeit slowly) to adopt clinical AI, how do patients feel about having their images interpreted by a computer? Researchers in a new study in JACR queried patients about their attitudes regarding mammography AI, finding that for the most part the jury is still out. 

Researchers got responses to a 36-question survey from 3.5k patients presenting for breast imaging at eight U.S. practices from 2023-2024, finding …

  • The most common response to four questions on general perceptions of medical AI was “neutral,” with a range of 43-51%. 
  • When asked if using AI for medical tasks was a bad idea, more patients disagreed than agreed (28% vs. 25%). 
  • Regarding confidence that medical AI was safe, patients were more dubious, with higher levels of disagreement (27% vs. 20%).
  • When asked if medical AI was helpful, 43% were neutral but positive attitudes were higher (35% vs. 19%).

The Takeaway

Much like clinicians, patients seem to be taking a wait-and-see attitude toward mammography AI. The new survey does reveal fault lines – like privacy and equitability – that AI developers would do well to address as they work to win broader acceptance for their technology. 

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Function Buys Ezra to Add Labs to Screening

Posted on by Brian Casey

In a major development in the wellness-screening segment, diagnostic lab screening company Function Health acquired full-body MRI firm Ezra. The companies plan to offer wellness screening that combines lab tests with imaging.

Ezra launched in 2018 with an initial focus on prostate MRI but soon expanded into full-body MRI screening.

  • The company has developed AI-enhanced image acceleration algorithms to acquire MRI scans in shorter time slots, enabling it to drive down costs to consumers.

Ezra’s scans are currently available at 100 U.S. locations with the goal of 1k sites in coming months (the company doesn’t run its own centers, but rather partners with existing imaging providers like AMRIC Health). 

  • Function Health has a similar strategy but in the clinical diagnostics space, offering blood tests available through some 2.2k Quest Diagnostics locations.

Function and Ezra believe that combining lab tests with imaging will support a new level of wellness screening that when coupled with AI will be even more predictive.

The Takeaway

The combination of Function Health and Ezra is an interesting wrinkle in the wellness screening space that promises to make screening even more comprehensive by acquiring both lab and imaging data. The question is whether other screening providers will feel compelled to follow suit.

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Integrated Solutions for Managing Incidental CAC Findings

Posted on by Partner Content

The rising prominence of coronary artery calcium as a prognostic marker for heart disease has created an emerging challenge for radiologists: how should they manage incidental CAC findings discovered on routine CT exams? Fortunately, new industry collaborations are making it possible to deliver CAC reports to clinicians without disrupting workflow. 

Routine CT scans are revealing data beyond their original diagnostic intent.

  • AI solutions – such as AVIEW CAC from Coreline Soft – play a pivotal role in identifying risks for cardiovascular disease, osteoporosis, and metabolic disorders – all from a single scan.

AI allows one CT scan to assess lung, cardiovascular, and skeletal health, improving diagnosis and treatment planning.

One imaging services provider that has put AVIEW CAC into use is 3DR Labs, which has been actively integrating the solution into its nationwide clinical network.

  • The partnership enables 3DR Labs radiologists to generate consistent, high-quality CAC reports directly within PACS, while significantly reducing turnaround times.

3DR Labs is finding that AVIEW CAC optimizes workflow efficiency and significantly reduces the time required for CAC assessment. 

  • It also ensures that radiologic technologists can perform quick QA checks, enhancing consistency and reliability in the delivery of the report.

The latest generation of the FDA-cleared AVIEW CAC features an upgraded user interface and advanced batch-scoring functionality. 

  • 3DR Labs is now working to expand AI-driven insights into lung and neuroimaging through Coreline’s broader AVIEW platform (AVIEW ILA for interstitial lung abnormalities and AVIEW BAS for brain CT).

Beyond diagnostic imaging, this collaboration supports growing demands for cost-efficiency in healthcare. 

  • As U.S. insurers and government agencies recognize the ROI potential of early AI detection, platforms like AVIEW CAC offer scalable, high-performance solutions that lower costs and streamline care delivery.

3DR Labs has also highlighted Coreline Soft’s role as a founding partner in AI Labs, the company’s vendor-neutral platform to deliver the latest AI innovations to radiology workflows.

The Takeaway

New partnerships like the collaboration between Coreline Soft and 3DR Labs are advancing the future of AI in radiology – focusing on automation, early detection, and better patient outcomes through powerful, clinically validated technologies. Such partnerships not only reflect increasing adoption of AI in U.S. healthcare but set the stage for global transformation in diagnostic imaging.

Imaging Cost Variation Narrows after Transparency Rule

Posted on by Brian Casey

Why do costs for medical imaging procedures vary so much between U.S. hospitals? This is one of radiology’s most enduring mysteries, but a new study in JACR shows that variation may be narrowing in the wake of federal transparency rules. 

It’s common knowledge that patients (and payors) can be charged differently for the same healthcare procedure based on the facility where it’s conducted. 

  • Previous studies have found that patients are surprisingly unclear on how much their imaging exams will cost them.

To clear things up, CMS in 2021 rolled out transparency rules for medical procedures that require healthcare providers to share cost information with patients. 

  • The rules specified 300 “shoppable” services, including 13 imaging procedures like mammography, abdominal ultrasound, and head CT and MRI scans.

But has the rule been effective in reducing cost variation? 

  • The new study tackles that question head-on, analyzing cost changes from 2023 to 2024 for three common outpatient imaging exams – MRI brain studies with and without contrast, chest radiographs, and nuclear medicine gastric emptying exams.

Researchers tracked prices for the three exams at 26 U.S. pediatric hospitals, finding …

  • The variation coefficient for all three procedures declined 19% (from 27% to 21%).
  • The greatest decline in variation was for nuclear medicine gastric emptying (-7.2%) while the smallest was for chest radiography (-2.2%).
  • Overall prices rose 6.7% for payor-specific negotiated rates even as variation declined.
  • Prices increased 7.7% for nuclear medicine gastric emptying, 6.6% for brain MRI, and 2.6% for chest radiography. 

Among the five commercial payors tracked (Aetna, Blue Cross Blue Shield, Cigna, Humana, and UnitedHealth), BCBS moved from having the second-lowest prices in 2023 to the lowest in 2024, while Humana was the highest-priced insurer in both years. 

The Takeaway

The new results are a classic good news/bad news scenario for radiology. While the reduction in price variation is a positive trend, it appears that the growth in healthcare costs is an inexorable force that even the best-intended legislation can’t derail. 

RadPartners + Envision Consolidate Imaging Services

Posted on by Brian Casey

In a stunning consolidation of the imaging services segment, Radiology Partners has agreed to take over radiology contracts currently held by debt-laden national medical group Envision Healthcare. The agreement could bring up to 100 imaging sites and hundreds of radiologists into the RadPartners fold. 

The takeover is a remarkable comedown for Envision, which was once one of the largest national medical practices in the U.S. and employed some 25k physicians when it was acquired in 2018 by private equity giant KKR. 

  • Envision’s business crossed multiple medical specialties, with its radiology operation at one point employing 800 radiologists who performed over 10 million reads per year. 

But Envision struggled under a $5.3B debt load imposed by the KKR buyout, and eventually filed for Chapter 11 bankruptcy protection in 2023 in a move that also included spinning off its ambulatory surgery business. 

  • Many industry observers have viewed Envision’s rise and fall as a cautionary tale illustrating the perils of private-equity investment in American medicine.

Radiology Partners itself has evolved into the giant of the imaging services segment as it rolls up local radiology practices into a massive national network. Under the agreement with Envision, RP will … 

  • Take over Envision’s contracts with some 95 client sites, including teleradiology. 
  • Potentially bring some 400 Envision radiologists onboard (assuming they want to join RP).

The question is, how many Envision radiologists will choose to go with the contracts and join Radiology Partners? 

  • Speculation on industry bulletin board RadHQ.net proposes that Envision radiologists will be offered new contracts with RP – contracts that they can take or leave.

The Takeaway

Radiology Partners’ takeover of Envision’s radiology contracts will only enhance RP’s dominance of the imaging services market, which is already significant. While that may be good news to RP’s investors, it probably won’t be encouraging to those worried about the inexorable corporatization of radiology. 

AI-Driven Diagnostics Detects Multiple Chest Diseases from Single CT Scan

Posted on by Partner Content

A new generation of AI solutions is enabling clinicians to detect multiple chest pathologies from a single CT scan. Lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease (COPD) can all be detected in just one imaging session, ushering in a new era of more efficient imaging that benefits both providers and patients. 

Advances in CT lung cancer screening have been generating headlines as new research highlights the improved clinical outcomes possible when lung cancer is detected early. 

  • But lung cancer is just one of a “big three” of thoracic comorbidities – the others being cardiovascular disease and COPD – that can result from long-term exposure to toxic substances like tobacco smoke. 

These co-morbidities will be encountered more often as health systems ramp up lung cancer screening efforts, creating challenges for radiologists in managing the many incidental findings discovered with chest CT scans.

  • And it’s common knowledge that radiologists already have their hands full in an era of personnel shortages and rising imaging volumes. 

Fortunately, new AI technologies offer a solution. One of these is Coreline Soft’s AVIEW LCS Plus, an integrated three-in-one solution that enables simultaneous detection of lung cancer, cardiovascular disease, and COPD from a single chest CT scan. 

  • AVIEW LCS Plus is the only solution adopted for national lung cancer screening projects across key countries, including Korea (K-LUCAS), Germany (HANSE), Italy (RISP), and the pan-European consortium (4ITLR). 

Coreline’s solution is widely recognized as a pioneering AI platform for an era where unexpected findings can save lives, gaining increasing attention in academic journals and health policy reports alike.

  • In the U.S., AVIEW LCS Plus has been adopted by Temple Health, and the Pennsylvania system’s use of the solution in their Temple Healthy Chest initiative has been recognized as an innovative healthcare model within the Philadelphia region. 

Temple Health clinicians are finding that AI contributes to early detection of incidental findings, improved survival rates, and more proactive care planning.

  • AVIEW LCS Plus is streamlining lung cancer screening, helping identify chest conditions at earlier stages, when treatment is most effective. It is finding not only lung nodules but also undetected comorbidities that were often missed with conventional CT workflow. 

Coreline Soft will be presenting AVIEW LCS Plus in collaboration with Temple Health at the upcoming American Thoracic Society (ATS 2025) international conference in San Francisco from May 16-21. 

  • Attendees will be able to learn how AI in medical imaging can establish new standards, not just in diagnostics, but across policy, patient care, and hospital strategy. 

Opportunistic Calcium Scoring Shifts to Abdomen

Posted on by Brian Casey

Most of the recent research on calcium scoring has focused on calcium in the coronary arteries and its link to cardiovascular disease. But a new study in American Heart Journal used abdominal CT scans with AI analysis for opportunistic measurement of abdominal aortic calcium to predict cardiac events – possibly earlier than CAC scores.

CT-derived CAC scores have become a powerful tool for predicting cardiovascular disease, helping physicians determine when to begin preventive therapy with treatments like statins.

  • CAC scores can be generated from dedicated cardiac CT scans, or even lung screening exams as part of a two-for-one test. 

Abdominal CT represents another promising area for calculating calcium. 

  • Previous research has found that atherosclerosis in the abdominal aorta may occur before its development in the coronary arteries, creating the opportunity to detect calcium earlier. 

Researchers from NYU Langone did just that in the new study, performing abdominal and cardiac CT scans in 3.6k patients and using an AI algorithm they developed in partnership with Visage Imaging to calculate AAC. They found that over an average three-year follow-up period … 

  • AI analysis of AAC severity was positively associated with CAC.
  • AAC could be used to rule out the presence of CAC relative to two versions of the PREVENT score (AUC=0.701 and 0.7802). 
  • The presence of AAC was associated with a higher adjusted risk of major adverse cardiovascular events (HR=2.18).
  • A doubling of the AAC score was linked to 11% higher risk of MACE.

The Takeaway

The new results are an exciting demonstration of opportunistic screening’s value, especially given the volume of abdominal CT scans performed annually. AI analysis of routinely acquired abdominal CT could give radiologists a tool for detecting heart disease risk even earlier than what’s possible with CAC scoring.

MRI Recon Gets Real with AI-Driven Protocols

Posted on by Brian Casey

AI-based data reconstruction for MRI scans took a step forward this week with studies showing how to generate 3T-like images from ultralow-field scanners, and improve scanner efficiency by cutting energy consumption.

MRI is radiology’s premier modality, but MRI scanners are cumbersome to install and expensive to operate. 

  • Ultralow-field scanners could help but some believe they lack the image quality for some clinical applications. 

Enter AI-based image reconstruction. Deep learning protocols are being developed for a wide range of imaging modalities, from PET to CT to MRI. 

  • These algorithms take images acquired with lower-quality input data – be it less CT radiation dose or lower MRI field strength – and upscale them to resemble full-fidelity images.

This trend is illustrated by research published this week in Radiology in which researchers tested a generative adversarial network algorithm called LowGAN for reconstructing data acquired on Hyperfine’s Swoop 0.064T portable ultralow-field MRI scanner.

  • Their goal was to enable Swoop to generate images resembling those acquired on a 3T system. 

After training LowGAN on paired 3T and 0.064T images, they tested the algorithm in 50 patients with multiple sclerosis and further validated it with a separate 13-patient cohort. They then judged LowGAN against several measures of MR image quality, finding that it …

  • Showed the biggest improvement on synthetic FLAIR and T1 images.
  • Improved conspicuity of white matter lesions, without introducing false lesions.
  • Increased consistency of cortical and subcortical volume measurements with 3T images.
  • But was unable to reveal brain lesions that were missed in the original low-field scans. 

AI-based data reconstruction also has environmental implications. Medical imaging is a major contributor to greenhouse gas emissions, and anyone who’s managed an MRI operation knows how much energy these massive scanners consume. 

  • A second paper published this week in Radiology described how MRI acceleration – scans acquired at a faster speed and then reconstructed for better image quality – reduced energy use, lowering carbon emissions while boosting imaging capacity. 

Researchers tried three techniques for speeding MRI acquisition – parallel acceleration, simultaneous multi-slice, and a deep learning algorithm. 

  • All three reduced energy consumption 21% to 65% and increased daily capacity by one to seven scanning slots, with deep learning showing the biggest effect.

The Takeaway

The new papers demonstrate an exciting future in which less powerful data acquisition technologies can be upscaled with AI to produce images that more closely resemble state-of-the-art scanning. The benefits will be enjoyed by both patients and the planet.

Patients Want Mammo AI, But Mostly As Backup

Posted on by Brian Casey

Patients support the idea of having AI review their screening mammograms – under certain conditions. That’s according to a new study in Radiology: Imaging Cancer that could have implications for breast imagers seeking to integrate AI into their practices.

Mammography screening has been identified as one of the most promising use cases for AI, but clinical adoption has been sluggish for reasons that range from low reimbursement to concerns about data privacy, security, algorithm bias, and transparency. 

  • Vendors and providers are working on solving many of the problems impeding greater AI use, but patient preference is an often overlooked factor – even as some providers are beginning to offer AI review services for which patients pay out of pocket.

To gain more insight into what patients want, researchers from the University of Texas Southwestern Medical Center surveyed 518 women who got screening mammography over eight months in 2023, finding …

  • 71% preferred that AI be used as a second reader along with a radiologist.
  • Only 4.4% accepted standalone AI interpretation of their images.
  • 74% wanted patient consent before AI review.
  • If AI found an abnormality, 89% wanted a radiologist to review their case, versus 51% who wanted AI to review abnormal findings by radiologists.
  • If AI missed a finding, 58% believed “everyone” should be accountable, while 15% said they would hold the AI manufacturer accountable. 

Patient preference for use of AI in collaboration with radiologists tracks with other recent research. 

  • Patients seem to want humans to retain oversight of AI, and seem to value trust, empathy, and accountability in healthcare – values associated with providers, not machines. 

The findings should also be good news for imaging services companies offering out-of-pocket AI review services. 

The Takeaway

The new findings should be encouraging not only for breast imagers and AI developers, but also for the imaging services companies that are banking on patients to shell out their own money for AI review. As insurance reimbursement for AI languishes, this may be the only way to move mammography AI forward in the short term.

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