Cancer Screening at ASCO 2025

The American Society of Clinical Oncology’s annual meeting isn’t usually known for diagnostic radiology research. But this week’s conference in Chicago included a number of radiology-related studies, particularly regarding cancer screening. 

Most ASCO meetings are dominated by new chemotherapy advances. 

  • But oncologists maintain a strong interest in cancer screening as the first step to guiding patients into advanced treatments.

At ASCO 2025, screening disparities were at the top of the agenda, as evidenced by the following presentations …

  • Mobile mammography addressed healthcare disparities for both urban and rural women in a study that analyzed demographics from 8.3k women screened. 
  • Patients served by mobile mammography in Pennsylvania were more likely to be Black (68% vs. 40%), uninsured (71% vs. 2.1%), and live in an economically deprived area (70% vs. 27%), and they also had higher recall rates (19% vs. 9.9%) and twice the median days to case resolution (29 vs. 14 days).
  • U.S. women who didn’t get mammography screening tended to be younger, uninsured, and have issues with medical costs.
  • Farther afield, Uzbekistan’s new breast screening program was described, with 83.6k women screened and 80% of cancers detected at an early stage.
  • The program also uses AI, with AI achieving higher AUC than a three-radiologist average (0.89 vs. 0.82) while reducing workload 41% with 3X lower recall.
  • In Saudi Arabia, AI was used to audit mammography reports for quality and compliance with BI-RADS guidelines. 
  • A virtual-first approach in California successfully reached candidates for colorectal and CT lung cancer screening, using an online platform with educational resources and scheduling. Of 71 people who met lung screening criteria, 24% completed CT scans, and of these 29% had clinically significant findings. 
  • To improve CT lung screening among low-income people of color, Indiana researchers enrolled 89 screening-eligible people in an educational program. Before the program 56% had never heard of lung cancer screening, but afterwards 100% said they believed screening could save their lives.
  • Ohio researchers found that of 116 lung cancer cases in a tumor registry, 24% got low-dose CT lung screening.
  • An IT tool detected patient concerns about screening’s cost – AKA financial toxicity – and assigned financial navigators to help them. 

The Takeaway
This week’s ASCO 2025 sessions demonstrate the synergy between screening and treatment that’s improving survival for a broad spectrum of cancer patients. Continued progress will only serve to benefit both disciplines.

Cancer Moonshot

The Biden administration “reignited” the US’ Cancer Moonshot initiative, setting a goal to halve the country’s age-adjusted cancer death rate within the next 25 years. Here’s how they plan to achieve this “Moonshot” of a goal, and what that means for imaging.

Cancer Moonshot History – Biden spearheaded the Obama administration’s Cancer Moonshot initiative, inspired by losing his son to brain cancer. The 7-year initiative used $1.8B in federal funding to improve cancer therapeutics, prevention, and detection through scientific discovery, collaboration, and data sharing.

The Reignited Moonshot – The revamped initiative inherits these same goals and approaches, while adding new focus areas and operational structures:

  • Overcoming the COVID pandemic’s cancer screening backlog
  • Addressing inequity in cancer incidence, detection, and care
  • Developing new treatments for rare and childhood cancers
  • Fast-tracking the development of multi-cancer tests
  • Improving the experience of cancer survivors and caregivers
  • Leveraging data to “turn our cancer care system into a learning system”
  • Creating a cancer research funding program modeled after DARPA
  • Appointing federal Cancer Moonshot leaders to coordinate this work

Imaging Alignment – Any government attempt to overcome cancer screening backlogs and to make early detection mainstream would surely result in more imaging, while the Moonshot initiative’s focus on “learning from data” could hold imaging AI upsides. That said, the announcement placed a much brighter spotlight on non-imaging areas (blood tests, vaccines, treatments), and few people on the clinical side of radiology believe more imaging is necessarily better for patients.

Moonshot Critics – The Cancer Moonshot initiative has its fair share of critics, who argued that cutting cancer deaths by 50% would require “curing” cancer (not just catching and treating it), expanding screening has downsides (radiation, unnecessary treatments), and that initiatives like this are largely done for appearances.

The Takeaway
The White House just made the fight against cancer a top administrative priority, meaning that a lot more government attention and resources are on the way, and notable changes in cancer imaging policies and volumes might follow.

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