Trimodal Platform | Radiation Deregulation | Lung CT Evidence

“Our nanoplatform is designed to enable multimodal molecular imaging, thus overcoming the intrinsic limitations of each single image modality while maximizing their advantages.”

Complutense University of Madrid’s Marco Filice on his team’s development of a hybrid nanoplatform that combines MRI, CT, and fluorescence optical imaging, reportedly locating and diagnosing tumors better than any of these modalities on their own.



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The Imaging Wire

A Trimodal Platform

Spanish researchers unveiled a new hybrid nanoplatform that combines MRI, CT, and fluorescence optical imaging to locate and diagnose tumors. The researchers believe this new multimodal molecular imaging platform can achieve more precise diagnosis than other MI modalities, and do it in just one session with just one contrast medium. Here’s how it works – the platform uses two-sided nanoparticles, with iron oxide embedded in a silica matrix on one side (for MRI) and gold on the other side (for CT), while a molecular probe on the gold side allows fluorescence optical imaging and peptide on the iron side’s silica surface identifies the tumor. The new platform achieved “excellent results” identifying fibrosarcoma in mice, but the researchers still have plenty to do before the nanoplatform is ready for humans.


Radiation Deregulation
It’s not everyday that The Imaging Wire and the Late Show with Stephen Colbert cover the same topic. The EPA is working on rule changes that would weaken the way radiation exposure is regulated. The proposed model would permit various exposure thresholds (vs. the current “there is no safe radiation level” model), claiming that the current rule creates billions in unnecessary costs AND… that low levels of radiation “can make people healthier.” Unsurprisingly, critics say this change would lead to greater radiation exposure across a range of professions (including medical workers) and they hate the “radiation is good for you” angle. The regulation change is now out for public comment, with no specific adoption date scheduled.


The State of the Ultrasound Market
A roundtable discussion published by 24x7mag.com provided a range of insights into the growth and evolution of the ultrasound market from the perspective of ultrasound leaders at Siemens Healthineers, Technical Prospects, GE Healthcare, Trisonics, and Philips. Here are some highlights:

  • Ultrasound growth has been driven by its combination of effectiveness, low cost, small footprint, improving image quality, and non-invasive/radiation-free operation, which make it ideal for a wider range of providers, applications, settings (e.g. acute care, primary care, orthopedics), regions (including developing markets), and patients
  • Increased adoption of AI, image guided therapy/interventions, and value-based care all favor ultrasound and will lead to ongoing growth
  • Ultrasound innovations largely focusing on automation, artificial intelligence support, workflow enhancements, precision health integration, interventional and treatment applications, and reduction in system sizes
  • Ultrasound will continue to take share from other modalities, particularly citing angiograms and breast cancer detection as applications that are shifting to ultrasound
  • Ultrasound’s growth is bringing some challenges including managing the increased workload of in-house HTM engineers and training/educating new ultrasound users
  • There is also work to do in order to convince more healthcare providers to rely on ultrasound, particularly due to the financial impact of the modality’s long procedure times and the need to educate healthcare professionals on why they should reduce patient radiation
  • The panelists also made a number of service-related recommendations including: adopting remote monitoring/service, using genuine OEM parts, working with manufacturer-direct service divisions (these three obviously came from OEM panelists), following official preventative maintenance schedules, promptly replacing any parts that appear worn, working with a reliable and low-cost parts supplier, and communicating with sonographers for insights into service/performance issues


NELSON Trial’s Call for Lung CT Screenings
The famed Dutch-Belgian “NELSON” trial (n=15,792) brought more support for lung cancer CT screening, finding that asymptomatic, at-risk men and women who had regular CT screening achieved 26% and 39% respective lower lung cancer mortality rates over 10 years (vs. control group). Overall, 157 lung cancer deaths occurred within the study’s CT screening group (vs. 250 in control group) with 69% of the screening group’s 243 total lung cancers detected at stage 1A or 1B and 10-12% detected at stage 4 (vs. 50% of cancers detected at stage 4 in control group). With this evidence in hand, the researchers were clear in their suggestion that this study should “inform and direct future CT screening programs worldwide.”


PwC Sees New Healthcare Provider Models Coming
PwC predicted that the next ten years will bring a major overhaul of healthcare provider business models, as traditional hospitals transform into four main models. The firm suggests that healthcare systems will adopt models defined as: Product Leaders (deliver advanced care for specific clinical areas with the best specialists and researchers), Experience Leaders (focused on providing the best customer experience, with a business goal of patient retention and loyalty), Integrators (offer the best customer value due to scale and scope, generally larger hospitals), and Health Managers (focus on population health by addressing social determinants of health to keep people out of high-cost settings). While flavors of these models exist across today’s healthcare landscape, the key takeaway here is that PwC clearly believes that the current healthcare provider models are due for an overhaul – and recent financials certainly support that theory.



The Wire


  • CNBC published a very favorable profile on GE Healthcare president and CEO, Kieran Murphy, diving into his ascent within GE Healthcare, Irish roots, no-nonsense “roll-up-your sleeves” style, and moves to diversify the healthcare division beyond imaging (into health IT, gene therapy, bioengineering, precision therapy, etc.). The story pivots to Murphy’s new task: managing the GE Healthcare spinoff and then driving growth once the separation is complete. Not sure if CNBC came up with this profile idea organically, but pieces like this are often pitched with a goal in mind.




The Resource Wire

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  • A University of Chicago survey found that 35% of patients have been surprised by a medical imaging bill. The Medmo healthcare marketplace eliminates billing surprises, allowing uninsured and underinsured patients to enter the price they can afford and schedule their procedure with an imaging provider willing to accept that same exact price.
  • In this Carestream video, an orthopedic surgeon opens up about why he decided to add the OnSight 3D Extremity System and how his practice benefits from the weight bearing CT.


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