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Ultrasound and DBT Screening, USPSTF Meeting Miss, and Ghost X-Ray
July 20, 2026
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Together with
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“The modest cancer detection rate of 1 per 1000 screens, coupled with the disproportionate false-positive and biopsy burden observed in our cohort, suggests that density-based ultrasound screening in the DBT era casts too wide a net with too little yield.”
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Dodelzon K et al, in a new study on supplemental ultrasound for breast screening with 2D mammography.
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Sunday’s World Cup championship was tension-filled battle between two titans of the sport. Congratulations to Spain and their partisans for the victory. Looking forward to seeing if La Roja can run it back in 2030! – Brian Casey, Managing Editor
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Ultrasound long ago carved out a role in breast cancer screening as a complementary tool to conventional 2D mammography. But is ultrasound still needed, now that U.S. breast screening programs have largely switched over to 3D digital breast tomosynthesis (DBT)? A new study in Academic Radiology raises questions.
Conventional 2D mammography has well-known shortcomings, particularly in women with dense breast tissue that can obscure lesions. So alternative modalities like ultrasound, breast MRI, and contrast-enhanced mammography (CEM) are called in to help when needed.
- Past research has shown that supplemental ultrasound can improve the cancer detection rate (CDR) in a 2D mammography screening program by 3-4 cancers per 1k women.
But those studies were performed before the switch to DBT, which can often see around overlapping structures thanks to a gantry head that acquires multiple images as it pans across the breast.
- So is ultrasound still needed in screening programs using DBT? Researchers from Weill Cornell Medicine at New York-Presbyterian Hospital tested the hypothesis by examining 103k screening exams from 2014 to 2024 in which both DBT and ultrasound were used.
In the study, researchers found that screening ultrasound after a negative DBT result…
- Generated 1.9k biopsies, or 19 biopsies for every cancer the modality detected.
- Produced an additional cancer detection rate of 1.0 per 1k women, compared to an additional CDR of 3-4 cancers for ultrasound in the 2D mammography era.
- Had an overall false-positive screening rate of 98.5%, a false-positive biopsy rate of 94.8%, and a positive predictive value of biopsies performed (PPV3) of just 5.2%.
- Generated $652k false-positive screening ultrasound costs and $1.16M in ultrasound-guided biopsy costs.
The numbers are sobering and indicate that the days of ultrasound as a supplemental screening modality to DBT screening could be coming to a close.
- Instead, the researchers recommended that ultrasound screening be replaced by more sensitive modalities like breast MRI or CEM, both of which are fortunately more available now than during the 2D mammography era.
The Takeaway
The new study answers the question – in the negative – of whether supplementary ultrasound is still needed in the era of DBT screening. The positive subtext here is that the research confirms the improved detection performance of 3D compared to 2D mammography.
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- ‘Ghost Imaging’ Could Slash X-Ray Radiation: An experimental technique dubbed “ghost imaging” could cut radiation dose dramatically. In a paper in Optica, researchers from China demonstrated ghost imaging using two X-ray beams: a strong beam, used as a reference, that doesn’t pass through the object being imaged, and a weaker beam that does. Along with technologies like X-ray crystal splitting and optimized digital detectors, they acquired test images with 0.5% of the photons typically required. More tests are needed before ghost imaging can be used clinically.
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- Lung Nodule AI Is Getting Better: As Europe implements large-scale CT lung cancer screening programs, is AI ready to help? A new literature review in European Radiology suggests it is, finding that over the last 12 years, the scientific evidence supporting AI for working up suspicious pulmonary nodules is becoming more sophisticated. The number of studies on nodule AI grew from 2012 to 2024 (from 14 to 95), and the percentage focusing on malignancy prediction also rose (from 6.7% to 29%).
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