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Mammography Use Falls, ACC Imaging News, and Ultrasound Breakthrough March 30, 2026
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Together with
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“Many radiology AI solutions fail. Not because the model was wrong. Because nobody asked the radiologist.”
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Woojin Kim, MD.
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Mammography use fell after the USPSTF rescinded its recommendation in 2009 of routine breast cancer screening for women in their 40s. The findings, in a new study in JAMA Network Open, confirm the fears of many women’s health advocates following the guideline change.
The women’s health world was shocked in 2009 when the USPSTF pulled its guideline advising women aged 40 to 49 to undergo regular breast screening, instead telling them to consult with their physicians.
- The group reversed course in 2024, stating that women in their 40s should be screened every two years. Driving the decision were rising cancer rates in younger women, as well as higher mortality rates among Black women.
The new study analyzed data from the Behavioral Risk Factor Surveillance System to find changes in mammography use among 2.6M women, divided into various groups based on age, race, and other demographics.
- Researchers analyzed self-reported mammography use, focusing on the periods 2000-2008 and 2012 and 2022.
The researchers found that, comparing 2002 to 2022, mammography prevalence fell for…
- Women aged 40 to 49 (from 70% to 59%).
- Women aged 50 to 74 (from 81% to 77%).
- Non-Hispanic Black women in their 40s (from 72% to 65%).
The researchers pointed out that for the above categories, the endpoint comparisons were statistically significant.
- But the year-to-year changes in intervening years were not, in particular given a change in BRFSS survey methodology in 2011 that appears to have led to a several-point drop in utilization.
But several subgroups of women saw changes in both endpoint and year-to-year mammography prevalence, with use falling among…
- Non-Hispanic White women in their 40s (from 71% to 60%).
- Women in their 40s with insurance (from 74% to 62%) and without (from 47% to 33%).
- Employed women (from 72% to 61%) as well as in women who classified themselves as homemakers (65% to 55%).
The Takeaway
The new study on falling mammography utilization confirms the fears of many women’s health advocates about the impact of the USPSTF’s 2009 guideline change. While the group righted the ship in 2024, it could take many years to see an effect – as suggested by the new study.
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Low Dose, Remarkably Open Design
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- Cardiac Imaging Dose Higher in Africa: Previous studies have found that radiation dose from imaging exams in developing countries is often much higher than in developed nations. A study presented at ACC 2026 found that average dose in Africa was shockingly high for coronary CT angiography compared to non-African countries (26 mSv vs. 6.6 mSv), and a higher percentage of African patients were scanned with older CT systems (45% vs. 16%). And if newer CT scanners were used, dose was no lower, unlike other countries.
- Echo AI Predicts Cardiac Amyloidosis Survival: In another talk at ACC 2026, researchers found that Us2.ai’s echocardiography AI algorithm predicted which cardiac amyloidosis patients had better odds of survival. In 649 patients who got a single apical four-chamber transthoracic echocardiogram, those with the lowest Us2.ai CA scores – indicating likelihood of less severe disease – had better survival odds (HR = 0.59). The findings indicate that the Us2.ai algorithm can provide not only diagnostic but also prognostic information about cardiac amyloidosis.
- CAC Guides Statin Treatment: CT-derived coronary artery calcium scores were used to guide lipid-lowering statin therapy in another ACC 2026 paper. Researchers calculated five-year atherosclerotic cardiovascular disease event rates in 5.9k people from the MESA study, finding that, compared to people with CAC scores of 0, hazard rates for ASCVD events rose with CAC scores, to a high of HR = 6.4 for scores over 300. At that CAC level, the five-year number needed to treat at a 20% relative risk reduction was just 19 patients.
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- AI Plaque Analysis Predicts Adverse Heart Events: Quantitative AI-based coronary plaque analysis predicted risk of major adverse cardiovascular events in a study presented at ACC 2026. Researchers used Heartflow’s AI-QCPA technique to analyze coronary CT angiography scans of 15.1k patients, finding that MACE risk increased with total plaque volume levels. Those with the highest TPV (>750 mm3) had nearly 4X higher risk of MACE (HR = 3.9).
- Cleerly Highlights at ACC 2026: Among the ACC 2026 highlights for Cleerly was a new workflow-support enhancement tool called Preview that’s designed to help clinicians prioritize cases and streamline administrative processes like prior authorization. On the research side, Cleerly highlighted a pair of CONFIRM 2 studies, one in which its AI-QCT technology quantified percent atheroma volume as a measure of plaque burden to guide revascularization procedures, and another in which AI-QCT stratified risk for major cardiovascular events in patients with and without diabetes.
- Active Surveillance for DCIS: Is active surveillance rather than surgical excision a good option for patients with ductal carcinoma in situ detected on screening mammography? Early results from the LORD trial in the Netherlands were presented last week from 1.4k patients with low-risk DCIS. Researchers say their trial supports surveillance, which had a lower invasive cancer rate compared to surgical excision (6% vs. 9%). But tumors in the active surveillance arm were larger (9 vs. 6 mm), and enough patients developed invasive cancer that the study was stopped.
- 4DMedical Gets CE Mark for CT:VQ: 4DMedical received the CE mark for CT:VQ, the company’s solution for assessing pulmonary function using CT scans. The technology is designed to replace nuclear medicine scans for ventilation-perfusion studies with CT, which is more widely available and easier to perform. CT:VQ received FDA clearancelast year. Separately, 4DMedical received commitments from institutional investors for USD$57M in a private placement to fund its growth, particularly in Europe.
- JLK Scores FDA Nod for Brain CT AI: South Korean AI developer JLK received FDA clearance for its AI algorithm to analyze non-contrast CT scans for signs of stroke. JLK-NCCT is intended to detect intracerebral hemorrhage while identifying patients with large-vessel occlusion, and enables non-contrast CT to be used to detect LVO without requiring patients to be sent on for CT angiography. The clearance is the latest for JLK, which has received a number of marketing authorizations in 2024 and 2025 for its AI algorithms.
- GE Extends Stanford Relationship: GE HealthCare extended its research collaboration with Stanford University with the goal of establishing a center of excellence to pursue research into MRI, CT, molecular imaging, and artificial intelligence. Stanford will continue working with GE on photon-counting CT technology like the company’s recently cleared Photonova Spectra scanner, and will also collaborate in developing a new total-body PET/CT system.
- Ultrasound AI Gets Breakthrough Nod: The FDA granted Breakthrough Device Designation to a prenatal AI ultrasound guidance platform developed by DeepEcho. The company’s Blind Sweep Platform guides users through acquisition of B-mode ultrasound scans, automating the acquisition of measurements like fetal presentation, placental location, and gestational age. DeepEcho will continue working with the FDA on regulatory authorization for the software, which would follow on a prenatal ultrasound algorithm the FDA cleared last year.
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